Sources which maintain the idea that increasing a Heart's Ejection Fraction is possible
The Heart Rhythm Society publishes a web page about Ejection Fraction which is of interest in the inquiry as to whether or not it is medically feasible to increase a heart's ejection fraction. Indeed, it is recommended by this article that if a patient limits their salt intake, manages fluid buildup through diuretics, exercises regularly, and if a doctor specializing in heart rhythm problems prescribes medicines specifically for increasing heart ejection fraction, then a patient may reasonably expect increases in heart ejection fraction measurements..
Ejection Fraction Levels:
50-75% Heart's pumping ability is Normal
36-49% Heart's pumping ability is Below Normal
At or below 35% Heart's pumping ability is Low
A video produced by St Jude Medical Heart Library is presented below that explains Ejection Fraction Measurements; how to interpret them; and expresses typically correct explanations that I have heard from doctors who specialize in heart therapies.
A video presentation by Dr. Juan Carlos Plana from the Cleveland Clinic states some interesting information to this novice about the parameters of interpretation of the ejection fraction measurement:
From the above data published by the Heart Rhythm Society on methods to increase a heart's ejection fraction, it is clear that a patient's heart ejection fraction is not a static quantity; and thus varies over time, depending upon various factors that either increase or decrease a heart's ability to pump blood. Although, I am no expert, not even a novice, (but a researcher, yes) I have been searching for valid therapies that may be attempted in the quest for effectively increasing a heart's ejection fraction. In this regard, I have identified several sources which indicate a couple directions that may be indicated:
Journal Paper #1: A paper discusses Nitric Oxide and Cardiac Function. The paper states that, "The reduction in (Nitric-Oxide dependent) NO-dependent coronary reserve is proportional to the impairment of cardiac function, because the magnitude of coronary blood flow reduction by (Nitric Oxide Synthase) NOS inhibition is inversely correlated to Left Ventricular ejection fraction." Source: https://doi.org/10.1161/01.HYP.30.1.50
Video #1: Findings from the Journal of the American College of Cardiology suggest that Ubiquinol taken in sufficient doses can reduce the mortality rates of patients having Congestive Heart Failure.
Vitamin B-1 deficiencies are talked about in the following video as it relates to Heart Failure and the use of Diuretics which block Vitamin B1 levels. The video recommends that B1 levels be checked and compensated for after the administration of a diuretic medicine.
A webpage from the Mayo Clinic tells us about their opinion on the efficacy of using Vitamin B-12 supplementary pharmaceutical level doses and grades it on a scale of A to F. On the two conditions that are indicated with a grade level of A, we have Megaloblastic Anemia and Vitamin B-12 deficiency. These conditions are applicable to patients who match these symptomatic syndromes and call for the administration of Vitamin B-12 at such levels according to the Mayo Clinic web page above cited. For Angioplasty, the grade level assigned is a C because there is an uncertainty regarding whether the evidence that giving prescription-strength folic acid and vitamins B12 and B6 for six months following coronary angioplasty reduced the risk of overall adverse cardiac events is true or not. More study seems to be indicated to remove the uncertainty. For Cardiovascular disease/hyperhomocysteinemia, the grade level assigned is also a C because there is an uncertainty regarding whether the evidence indicates that lowering homocysteine levels has an effect on cardiovascular disease risk and death. Where conditions that warrant the prescription of Vitamin B-12 under A Grade conditions exist while also C Grade conditions exist, it couldn't be hurtful to provide the noted prescription strength doses of folic acid and Vitmins B6 and B12 as well.
On Vitamin B-12 doses: There is a video that advocates the use of Vitamin B-12 and suggests this at particular dosage levels when using it to increase ejection fraction. This could aid a doctor in prescribing such and for us to contribute to the studies that would help solidify clinical research on this topic: